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S22E01: Only the Strong Survive

After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

Genres:

Air Date:

Oct 09, 2025

Production:

The Mark Gordon Company , ShondaLand , ABC Studios , Touchstone Television

Casts:

Chandra Wilson, James Pickens Jr., Kevin McKidd, Caterina Scorsone, Camilla Luddington, Kim Raver, Chris Carmack, Jake Borelli, Anthony Hill, Adelaide Kane, Alexis Floyd, Niko Terho, Midori Francis, Harry Shum Jr.

Grey's Anatomy

A Hard Day's Night

The First Cut is the Deepest

Winning a Battle, Losing the War

Shake Your Groove Thing

If Tomorrow Never Comes

The Self-Destruct Button

Who's Zoomin' Who?

Raindrops Keep Falling On My Head

Enough is Enough (No More Tears)

Make Me Lose Control

Deny, Deny, Deny

Into You Like a Train

Something to Talk About

Thanks for the Memories

Owner of a Lonely Heart

Grandma Got Run Over By a Reindeer

Begin the Begin

Tell Me Sweet Little Lies

Break on Through

It's the End of the World

What Have I Done to Deserve This?

Band-Aid Covers the Bullet Hole

The Name of the Game

Blues for Sister Someone

Deterioration of the Fight or Flight Response

Losing My Religion

Time Has Come Today

Sometimes a Fantasy

Let the Angels Commit

Where the Boys Are

Staring at the Sun

From a Whisper to a Scream

Don't Stand So Close to Me

Great Expectations

Wishin' and Hopin'

Drowning on Dry Land

Some Kind of Miracle

Scars and Souvenirs

My Favorite Mistake

Time After Time

The Other Side of This Life (1)

The Other Side of This Life (2)

Didn't We Almost Have It All?

A Change Is Gonna Come

Let the Truth Sting

The Heart of the Matter

Haunt You Every Day

Kung Fu Fighting

Physical Attraction, Chemical Reaction

Crash Into Me (1)

Crash Into Me (2)

Lay Your Hands on Me

Where The Wild Things Are

Piece of My Heart

Dream a Little Dream of Me (1)

Dream a Little Dream of Me (2)

Here Comes the Flood

Brave New World

There's No 'I' in Team

Life During Wartime

These Ties That Bind

In the Midnight Hour

Wish You Were Here

Sympathy for the Devil

Stairway to Heaven

Beat Your Heart Out

Before and After

An Honest Mistake

I Will Follow You Into the Dark

Elevator Love Letter

Sweet Surrender

No Good at Saying Sorry (One More Chance)

What a Difference a Day Makes

Here's to Future Days

I Always Feel Like Somebody's Watchin' Me

Tainted Obligation

I Saw What I Saw

Give Peace a Chance

I Like You So Much Better When You're Naked

State of Love and Trust

Valentine's Day Massacre

Perfect Little Accident

Suicide is Painless

Sympathy for the Parents

Hook, Line and Sinner

How Insensitive

Shiny Happy People

Death and All His Friends

With You I'm Born Again

Shock to the System

Can't Fight Biology

These Arms of Mine

That's Me Trying

Something's Gotta Give

Slow Night, So Long

Adrift and at Peace

Don't Deceive Me (Please Don't Go)

P.Y.T. (Pretty Young Thing)

Not Responsible

This is How We Do it

Song Beneath the Song

It's a Long Way Back

Unaccompanied Minor

What is it About Men?

Love, Loss and Legacy

Put Me In, Coach

Heart-Shaped Box

Dark Was the Night

This Magic Moment

Hope for the Hopeless

All You Need is Love

Have You Seen Me Lately?

If Only You Were Lonely

One Step Too Far

The Lion Sleeps Tonight

The Girl with No Name

Moment of Truth

Let the Bad Times Roll

Going Going Gone

Remember The Time

Love the One You're With

I Saw Her Standing There

I Was Made for Lovin' You

Love Turns You Upside Down

Things We Said Today

The End is the Beginning is the End

Walking on a Dream

The Face of Change

This is Why We Fight

Transplant Wasteland

Can't Fight This Feeling

She's Killing Me

Sleeping Monster

Do You Believe in Magic?

Readiness is All

I Want You with Me

Everybody's Crying Mercy

Puttin' on the Ritz

Two Against One

Sorry Seems to Be the Hardest Word

Somebody That I Used To Know

Man on the Moon

Get Up, Stand Up

You've Got to Hide Your Love Away

Throwing it All Away

We Gotta Get Out of This Place

Change of Heart

We Are Never Ever Getting Back Together

Everything I Try to Do, Nothing Seems to Turn Out Right

Fear (of the Unknown)

I Must Have Lost It on the Wind

Puzzle with a Piece Missing

Only Mama Knows

Don't Let's Start

Could We Start Again, Please?

Where Do We Go from Here?

The Bed's Too Big Without You

All I Could Do Was Cry

The Great Pretender

Staring at the End

I Feel the Earth Move

Don't Dream It's Over

With or Without You

One Flight Down

How to Save a Life

She's Leaving Home (1) & (2)

Old-Time Rock-and-Roll

Guess Who's Coming to Dinner?

The Me Nobody Knows

Something Against You

Things We Lost in the Fire

The Sound of Silence

All I Want Is You

Unbreak My Heart

I Am Not Waiting Anymore

When It Hurts So Bad

I Wear the Face

There’s a Fine, Fine Line

It’s Alright, Ma (I’m Only Bleeding)

You're Gonna Need Someone on Your Side

Catastrophe and the Cure

I Ain't No Miracle Worker

Why Try to Change Me Now

The Room Where It Happens

You Haven't Done Nothin'

You Can Look (But You'd Better Not Touch)

None of Your Business

It Only Gets Much Worse

Back Where You Belong

Who Is He (And What Is He To You)?

'Til I Hear It from You

Be Still, My Soul

In the Air Tonight

Don't Stop Me Now

Leave It Inside

Break Down the House

Get Off on the Pain

Go Big or Go Home

Ain't That a Kick in the Head

Come on Down to My Boat, Baby

Who Lives, Who Dies, Who Tells Your Story

(Don't Fear) the Reaper

Harder, Better, Faster, Stronger

You Really Got a Hold on Me

Games People Play

Old Scars, Future Hearts

Caught Somewhere in Time

One Day Like This

Hold Back the River

Beautiful Dreamer

Fight for Your Mind

With a Wonder and a Wild Desire

Broken Together

Momma Knows Best

Flowers Grow Out of My Grave

Anybody Have a Map?

Blowin' in the Wind

Shelter from the Storm

Help, I'm Alive

The Winner Takes It All

Girlfriend in a Coma

I Walk the Line

I Want a New Drug

We Didn't Start the Fire

Blood and Water

And Dream of Sheep

Silent All These Years

The Whole Package

Head Over High Heels

What I Did for Love (I)

Drawn to the Blood

Jump into the Fog

Nothing Left to Cling To

Back in the Saddle

It's Raining Men

Whistlin' Past the Graveyard

Papa Don't Preach

Let's All Go to the Bar

Help Me Through the Night (II)

A Hard Pill to Swallow

The Last Supper

Save the Last Dance for Me

Leave a Light On

Give a Little Bit

Love of My Life

Put on a Happy Face

All Tomorrow’s Parties

The Center Won't Hold

My Happy Ending

You'll Never Walk Alone

Fight the Power

No Time for Despair

Helplessly Hoping

It's All Too Much

Sorry Doesn't Always Make It Right

Sign O' the Times

I'm Still Standing

Someone Saved My Life Tonight

Here Comes the Sun (II)

Some Kind of Tomorrow

Hotter Than Hell

With a Little Help from My Friends

Bottle Up and Explode!

Every Day is a Holiday (With You)

Today Was A Fairytale

It Came Upon A Midnight Clear

Living in a House Divided

The Makings Of You

Put The Squeeze On Me

Road Trippin’

Put It To The Test

Should I Stay or Should I Go?

Stronger Than Hate

You Are the Blood

Everything Has Changed

Wasn't Expecting That

Let's Talk About Sex

When I Get to the Border

I'll Follow the Sun

Love Don't Cost a Thing

Sisters Are Doin' It for Themselves

Pick Yourself Up

Cowgirls Don't Cry

Shadow of Your Love

Mama Who Bore Me

Gunpowder and Lead

Come Fly with Me

Wedding Bell Blues

Happily Ever After?

We've Only Just Begun

Keep the Family Close

Walk on the Ocean

Baby Can I Hold You

Never Felt So Alone

The Marathon Continues

She Used to Be Mine

Blood, Sweat and Tears

I Carry Your Heart

If Walls Could Talk

Take Me to Church

I Can See Clearly Now

This One's for the Girls

You Make My Heart Explode

Drop It Like It's Hot

Jump (For My Love)

I Still Haven't Found What I'm Looking For

Don't You (Forget About Me)

Love in the Ice Age

Bust Your Windows

Papa Was a Rollin' Stone

Love You Like a Love Song

Only the Strong Survive

We Built This City

Between Two Lungs

Sometimes I Feel Like a Motherless Child

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